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微小RNA与肿瘤浸润转移 被引量：1

MicroRNA＇ s function in neoplasm invasiveness and metastasis
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摘要 微小RNA（miRNA）在多数肿瘤中存在异常表达，能在转录后水平调控靶基因的表达，发挥促进或抑制肿瘤浸润转移的作用，其自身的表达也受表观遗传学静息等多种机制的调节。miRNA作为一种理想的标记物，有望成为临床肿瘤治疗的新靶点。 MicroRNA（miRNA） is expressed in most malignant tumors. MiRNA plays important roles in promoting or inhibiting tumor invasion and metastasis through regulating specific gene expression posttranscriptionlly. Deregulation of miRNA can be attributed to multiple mechanisms, such as epigenetic silencing. As an ideal biomarker, miRNA might be a useful therapeutic target in treatment of malignancies clinically.
作者 李俊(综述) 鹿欣(审校)
机构地区 复旦大学附属妇产科医院妇科
出处 《国际肿瘤学杂志》 CAS 2010年第2期104-106,共3页 Journal of International Oncology
关键词 微小RNA 肿瘤 肿瘤浸润 肿瘤转移 MicroRNA Neoplasms Neoplasm invasiveness Neoplasm metastasis
分类号 R73-37 [医药卫生—肿瘤]
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共引文献207

同被引文献17

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国际肿瘤学杂志
2010年 第2期

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