非小细胞肺癌中血管内皮生长因子与树突细胞的关系

Relationship between vascular endothelial growth factor and dendritic cells in non-small cell lung cancer

血管内皮生长因子（VEGF）是重要的肿瘤细胞生长因子之一，其可以抑制树突细胞（DC）的分化成熟，诱导成熟DC功能障碍，而DC亦可通过自分泌VEGF加重自身的功能障碍，从而介导肿瘤细胞逃逸免疫监视。因此VEGF和DC的相互关系与非小细胞肺癌（NSCLC）的分化程度、淋巴结转移、临床分期密切相关。二者关系可为临床NSCLC的治疗提供相应理论依据。

Vascular endothelial growth factor（VEGF） is recognized as a key factor in tumor, which can hamper dendritic cells（DC） to mature. Thus DC can secrete VEGF to induce self-dysfunction,to induce tumor cells escaping from immune surveillance. The relationship between VEGF and the DC is closely related with the differentiation, clinical stages and lymph node metastasis in non-small-cell lung carcinoma（NSCLC）. It can provide appropriate theoretical basis for clinical treatment of NSCLC.