食管癌组织内微血管定量与转移关系的研究

A Study on Relation between Metastasis and Fixed Quantity of Micrangium in Esophageal Carcinoma Tissue

目的观察食管鳞状细胞癌组织内微血管定量、分布与食管旁淋巴结转移的关系。方法应用第Ⅷ因子相关抗原免疫组化方法，对４０例食管癌组织中微血管定量与淋巴结转移的关系进行研究。结果食管早期鳞癌的微血管密度为３７．４±１６．３个／ＨＰ，中晚期鳞癌为５９．６±１３．５个／ＨＰ，两组间的差异有显著意义（Ｐ＜０．００１）；有淋巴结转移者微血管密度高于无淋巴结转移者。

Objective To inveatigate the density, distribution of micrangium in tissue of esophageal squamous cell carcinoma and to study their relation to metastasis to lymph nodes by the side of esophagus.Methods With correlative antigen of factor VIII immunohistochemical method, the relation between metastasis to lumph nodes and fixed quantity of micrangium (FQOM) in esophageal carcinoma tissue of 40 cases was studied.Results The density of FQOM in early esophageal squamous cell carcinoma is 37.4±16.3 m/HP (m/HP = microangium per high power), and that in middle and late stage is 59.6±13.5 m/HP, the difference between two groups being very significant ( P <0.001); the density of FQOM in metastatic group is higher than that in non metastatic group.Conclusion The results suggest that there be close relations between the FQOM and the degree of cancer cell differentiation and between that and esophageal lymph node metastasis.