杭州市无脊髓灰质炎时期急性弛缓性麻痹监测及残留麻痹病例调查分析

Surveillance of acute flaccid paralysis and investigation of residual paralysis cases in Hangzhou in a polio-free period

目的了解杭州市急性弛缓性麻痹(AFP)病例及残留麻痹流行病学特征和疾病谱。方法根据全市13个区、县(市)2001-2008年连续8年的AFP病例监测,进行系统评估。结果连续8年共有AFP病例181例,无脊髓灰质炎确诊病例,AFP病例报告发病率在1.59/10万～3.09/10万之间。181例AFP病例共残留麻痹21例,占总病例的11.60%。5岁以下16例,占残留麻痹病例的76.19%,病例以格林巴利综合征为主,共12例,占残留麻痹病例的57.14%。结论连续8年的AFP监测表明,杭州市的AFP病例监测系统处于敏感状态。AFP病例中残留麻痹以格林巴利综合征为主。

Objective To evaluate the epidemiologic characteristics and disease spectrum of cases of acute flaccid paralysis（AFP） and residual paralysis in Hangzhou.Methods A systematic evaluation was conducted on the basis of the AFP surveillance results in 13 districts and counties of Hangzhou for 8 consecutive years from 2001 to 2008.Results A total of 181 AFP cases were found in the 8 consecutive years,without confirmed polio cases.The reported incidence rate of AFP cases ranged from 1.59/105 to 3.09/105.There were 21 residual paralysis cases of the 181 AFP cases,accounting for 11.60%,and 16 of them were younger than five,accounting for 76.19% of all residual paralysis cases.The majority of the residual paralysis cases,a total of 12 cases,were caused by Guillain-Barre syndrome,accounting for 57.14%.Conclusion The AFP surveillance results for 8 consecutive years suggested that the surveillance system of AFP cases in Hangzhou was sensitive.Guillain-Barre syndrome was the culprit of residual paralysis in most AFP cases.