近5年我院临床分离革兰阳性球菌主要种类及耐药分析

Category of Clinically Isolated Gram-positive Bacterium in Our Hospital and Their Drug Resistance in Recent 5 Years

目的:了解我院临床分离革兰阳性(G+)球菌主要种类及耐药状况。方法:对近5年我院临床分离的G+球菌主要种类及耐药情况进行回顾性调查并作统计分析。结果:临床分离G+球菌中葡萄球菌占65.47%,肠球菌占20.24%。葡萄球菌以凝固酶阴性葡萄球菌为主,其次为金黄色葡萄球菌;肠球菌主要为屎肠球菌、粪肠球菌。葡萄球菌对呋喃妥因、利福平耐药率较低,对万古霉素的敏感率达100%。屎肠球菌与粪肠球菌对常用抗菌药物耐药率存在差异,万古霉素仍是治疗肠球菌最有效的药物。结论:临床医师应及时掌握细菌构成及耐药谱,提高抗菌药物合理使用水平。

OBJECTIVE：To probe into the category and drug resistance of clinically isolated gram-positive bacterium（G＋）in our hospital. METHODS：The category and drug resistance of clinically isolated gram-positive bacterium（G＋）in our hospital in the recent five years were surveyed and analyzed retrospectively. RESULTS：Of clinical isolated gram-positive bacterium（G＋）, Staphylococcus accounted for 65.47% and Enterococcus 20.24%. Majority of Staphylococcus were coagulase negative Staphylococcus,followed by Staphylococcus aureus. The most of Enterococcus were Enterococcus faecium and Enterococcus faecalis. The drug resistance rates of Staphylococcus to nitrofurantoin and ifampin reached low level and the sensitivity of Staphylococcus to vancomycin was 100%. There was difference between drug resistance of Enterococcus faecium and Enterococcus faecalis. Vancomycin has better effect than other drugs on Enterococcus. CONCLUSIONS：Doctors must pay attention to the component and drug resistance of bacteria so as to improve the application of antibiotics.