我院432例抗癫痫药血药浓度监测数据分析

Analysis on Monitoring and Measuring Data of Plasma Concentration of Antiepileptic Drugs of 432 Cases in Our Hospital

目的:分析抗癫痫药血药浓度监测结果,为临床合理用药提供参考。方法:建立抗癫痫药Access数据库,对我院2001年1月～2009年6月4种常用抗癫痫药的血药浓度监测结果进行统计、分析。结果:我院抗癫痫药血药浓度监测例数大体呈逐年上升趋势,共监测432例/次;血药浓度在治疗窗内所占比例为48.6%;卡马西平、苯巴比妥、苯妥英钠、丙戊酸钠血药浓度在治疗窗内的有效率分别为91.3%、77.8%、62.5%、88.2%;儿童(0～10岁)与老人(>60岁)进行血药浓度监测例数占总监测例数的22.2%;有43例采用抗癫痫药联合给药方案,占总例数的10%,其中偏离正常治疗浓度范围的有27例,占62.8%。结论:血药浓度监测结果是指导临床用药的重要依据之一,结合其他临床指标综合分析,可最大限度地促进抗癫痫药合理应用。

OBJECTIVE：To analyze the monitoring and measuring data of plasma concentration of antiepileptic drugs in order to provide reference for rational use of drug in the clinic. METHODS：Access database of antiepileptic drugs was established to analyze the monitoring and measuring data of 4 kinds of antiepileptic drugs from Jan. 2001 to Jun. 2009 statistically. RESULTS：The case number of plasma concentration monitoring of antiepileptic drugs increased year by year. A total of 432 cases were involved. 48.6% of cases were in the effective plasma concentration range. Effective rates were 91.3% for carbamazepine,77.8% for phenobarbital,62.5% for sodium phenytoin and 88.2% for sodium valproic acid when plasma concentration was in the normal range. 22.2% of cases were children（aged from 0 to 10）and the old（60 years old）. 43 cases of antiepileptic drugs combination accounted for 10% and the therapeutic plasma concentration of 27 cases deviated from normal range（62.8%）. CONCLUSION：Results of plasma concentration monitoring provide an important basis for clinical drug use. Monitoring data and other clinical index can promote rational use of antiepileptic drugs.