我院494例门诊患者药品不良反应报告分析

Analysis on 494 ADR Cases of Out-patients in Our Hospital

目的:了解我院门诊患者药品不良反应(ADR)发生的特点及规律。方法:对我院2007～2008年门诊药房收集到的494例ADR报告进行回顾性分析。结果:494例ADR报告中,女性发生率(62.96%)明显高于男性(37.04%);静脉给药最易导致ADR(58.50%);ADR发生率最高的为抗菌药物(51.21%),其中又以氟喹诺酮类(104例)和大环内酯类(90例)抗菌药物最为普遍,其次为心脑血管系统药(13.97%)和中药制剂(13.16%);ADR的临床表现主要为皮肤及其附件损害(29.17%)、消化系统损害(22.37%)和神经系统损害(17.34%)。结论:应重视临床ADR监测,为临床合理用药提供参考。

OBJECTIVE： To investigate the characteristics and regularity of adverse drug reactions （ADR） of out- patients occurred in our hospital. METHODS： 494 cases of ADR cases collected in our out- patient dispensary from 2007 to 2008 were analyzed retrospectively. RESULTS： Of total 494 ADR cases,ADR incidence of female （62.96%） was obviously higher than male （37.04%）. 58.50% of ADR cases were induced via intravenouse route drugs and 51.21% were caused by antibiotics,among which 104 cases were caused by fluoroquinolones and 90 cases by macrolide,followed by the cardiovascular and cerebral system drugs （13.97%） and traditional Chinese medicine （13.16%）. The main clinical manifestations of ADR cases were lesion of skin and appendant （29.17%）,injury of digestive system（22.37%） and nervous system（17.34%）. CONCLUSION： More attention should be paid to the ADR monitoring to provide reference for clinical rational use of drug.