薯蓣皂苷片治疗急性非ST段抬高性心肌梗死临床研究

Dioscornin tablets in the treatment of acute non-ST elevation myocardial infarction

【目的】观察薯蓣皂苷片治疗急性非ST段抬高性心肌梗死的安全性及疗效。【方法】112例患者随机分为2组,治疗组56例,对照组56例,均予标准化治疗:注射低分子肝素、服用阿司匹林及抗心绞痛药物,治疗组在标准治疗基础上加用薯蓣皂苷片。28d后观察治疗前后心绞痛发作频率、心电图改善、血液流变性、血脂、心脏事件发生率。【结果】治疗组在心绞痛发作频率、心电图、血流变、血脂、心脏事件发生率上与对照组相比均有显著性差异(P<0.05);治疗组心脏事件的发生率低于对照组(P<0.05)。【结论】薯蓣皂苷片能降低急性非ST段抬高性心肌梗死患者心绞痛的再发率,降低血脂、并减少心脏事件的发生率,改善心肌缺血。

[Objective]To observe the clinical effect and safety of Dioscornin tablets on acute non-ST elevation myocardial infarction（NSTEMI）. [Methods]A total of 112 patients with acute NSTEMI were divided into treatment and control group randomly.Control group was administered by low molecular heparin,aspirin and other anti-anginal drugs. Dioscornin Tablets were given in the treatment group in addition to the drugs given to the control group. Frequency of attack of angina pectoris,ECG,hemorrheology,blood-lipids were determined at one day before and 28 d after treatment. [Results] In group A,the improvement in angina patoris attack,ECG,hemorrheology,blood-lipids were significantly superior to those in group B （P 0.05）;The number of heart events was also significantly reduced. [Conclusions] Dioscornin tablets is an effective and safe drug in the treatment of acute NSTEMI.