异基因造血干细胞移植中兔抗人胸腺细胞免疫球蛋白输注发热的护理

Nursing of fever during infusion procedure of rabbit Anti-Human T-lymphocyte Immunoglobulin in allogeneic hematopoietic stem cell transplantation

目的探讨降低兔抗人胸腺细胞免疫球蛋白（ATG）在异基因造血于细胞移植预处理过程中引起发热不良反应的护理要点。方法对59例输注ATG的患者随机进行分组，观察组（n=31）采用改良ATG输注的方法，对照组（n=28）采用常规方法。对两组发热资料进行统计学分析。结果第1天发热发生率观察组为55％，对照组为82％；观察组1个疗程中均未出现发热为35％，对照组为10％，两组差异有统计学意义（P〈0．05）。结论在ATG输注过程中，严密观察，早期护理干预，其输注过程中发热的症状可以得到有效控制，其发生率明显降低，临床护理中值得借鉴。

Objective To explore the effective nursing interventions on reducing the incidence of fever during infusion procedure of Anti-Human T-lymphocyte Immunoglobulin （ATG） in allogeneic peripheral blood stem cell transplantation （ allo-PBSCT ）. Methods Conventional infusion procedure was modified. Fifty-nine patients using ATG in allo-PBSCT were randomly divided into two groups. Thirty-one in study group were infused with modified procedure and 28 in control group were infused with conventional procedure. Statistical analysis for clinical data of fever was performed. Results Modified procedure decreased the incidence rate of fever at the first day, which was 82% in conventional group versus 55 % in control group （P 〈 0. 05 ） and fever- free rate of two groups was 35% and 10% respectively （ P 〈 0. 05 ）. Conclusions Intensive observation and early nursing intervention can reduce the incidence of fever during infusion procedure of ATG.