盐酸帕罗西汀对卒中后抑郁及神经功能恢复的影响

Effect of Paroxetine Hydrochloride on post-stroke depression and recovery of neurological function

【目的】观察盐酸帕罗西汀对卒中后抑郁及神经功能恢复的影响。【方法】将95例急性卒中后抑郁患者随机分为盐酸帕罗西汀组(48例)和对照组(47例),2组均接受常规药物治疗,治疗组同时加用盐酸帕罗西汀治疗。治疗前、治疗后4、8周应用Hamilton抑郁量表(HRSD)评价抑郁状况,采用简易智能状态量表(MMSE)、临床神经功能缺损程度评分(SSS)评价患者的认知和神经功能状况。【结果】治疗后4周、8周时盐酸帕罗西汀组HRSD总分比对照组显著降低(P<0.01),MMSE评分较对照组显著增加(P<0.01)。盐酸帕罗西汀组治愈率和总有效率分别为61.22%和95.91%,显著高于对照组的15.213%和58.69%(P<0.05)。治疗4周后两组SSS评分均有所下降,但无显著差异;治疗8周后盐酸帕罗西汀组SSS评分明显低于对照组(P<0.01)。【结论】盐酸帕罗西汀治疗卒中后抑郁有效,能改善患者情感状态及促进神经功能恢复。

[Objective]To observe the effect of Paroxetine Hydrochloride on post-stroke depression and recovery of neurological function.[Methods]A total of 95 patients of acute post-stroke depression were randomized into Paroxetine Hydrochloride group（48 cases）and control group（47 cases）.Conventional therapy was given to both groups and to the treatment group Paroxetine Hydrochloride was given at the same time.Depression status was assessed with Hamilton Rating Depression Scale（HRSD）,and cognitive and neurological functional status with Mimi-Mental State Examination（MMSE）and（SSS）.[Results] After 4 to 8 weeks＇ treatment,the total score of HRSD of Paroxetine Hydrochloride group were significantly lower than the control group（P〈0.01）and MMSE score increased significantly（P〈0.01）.The curative rate and effective rate of Paroxetine Hydrochloride group were 61.22% and 95.91%,significantly higher than the 15.213% and 58.69% of the control group（P〈0.01）.4 weeks later,the SSS score in both groups decreased,but there was no significant difference.8 weeks later,the SSS score of Paroxetine Hydrochloride group was significantly lower than the control group（P〈0.01）.[Conclusions] Paroxetine Hydrochloride is effective to treat post-stroke depression.It can improve the emotional state of patients and give a promotion of neurological function recovery.