狭窄冠脉致犬心肌缺血模型在清醒与麻醉状态下的比较

Comparison on difference of myocardial ischemic models induced by coronary artery stenosis between conscious and anesthetic dogs

目的:比较狭窄冠状动脉导致心肌缺血模型犬在麻醉和清醒状态下的差异,及药物治疗的差异。方法:在无菌条件下给犬心外膜安置心电电极、血压导管、信号发射器并分离冠状动脉前降支,放置动脉压迫环。手术恢复期后,动物按正交设计给予处置:分别在清醒与麻醉状态下狭窄冠状动脉,进行模型组和硝酸甘油治疗组的观察。主要监测心外膜心电图ST段、血压、心率、体温。结果与结论:麻醉犬心率明显高于清醒犬,冠脉狭窄后麻醉及清醒犬心电图ST段均明显升高;硝酸甘油治疗的效果,清醒犬较麻醉犬起效快,维持时间长。

Objective： Using model of myocardial ischemia by coronary artery stenosis with artery tings, the difference between anesthetized and conscious dogs, as well as drug treatment, was compared. Methods： Under sterile conditions, electrode of epicardial ECG, catheter of blood pressure, and the signal transmitter were imbedded in Beagle dogs, and the artery tings were placed on anterior descending coronary artery. After surgery, the coronary artery stenosis was made in anesthetized or conscious state according to orthogonal design, the therapeutic effect of nitroglycerin or vehicle was observed. Data of epicardial ECG ST-segment, blood pressure, heart rate, and body temperature were acquired and analyzed. Results and Conclusion： Heart rate was higher in anesthetic dogs than that in conscious dogs. Epicardial ECG ST-segment was increased both in conscious and anesthetic dogs significantly after coronary artery stenosis. Therapeutic effects of nitroglycerin provide faster onset of action and longer time in conscious dogs compared with anesthetic dogs.