何首乌中鞣质对大鼠肝脏生化指标的影响

Effect of tannin in Polygonum multiflorum on liver biochemical indexes of rats

目的:研究何首乌中提取出的鞣质对大鼠肝脏生化指标的影响。方法:每天按不同剂量(分别相当于成人每日30g/60kg体质量临床用量的25、50、100倍)ig大鼠1次,连续给药90d,恢复期15d。分别于第60、90、105天采取动物血液进行生化指标的检测。结果:给药组与对照组相比,给药60d时大鼠血清中ALT大剂量组显著升高(P<0.01),中剂量组升高(P<0.05);ALP中、小剂量组有所降低(P<0.05);TG大剂量组升高(P<0.05);GGT大、小剂量组升高(P<0.05);TBIL大、中、小剂量组均显著性降低(P<0.01)。给药90d后大剂量组大鼠血清ALT、GGT均升高(P<0.05)。恢复15d后各项指标与对照组均无显著差异。结论:何首乌中提取的鞣质长期ig大剂量对大鼠肝脏有损害,中剂量短期内对肝脏有所损害,小剂量无明显肝损害,但其对肝脏的损害在停药后均可以恢复。

Objective： To study the effects of tannin in Polygonum multiflorum on rats＇ biochemical indexes in liver of rats. Methods： The rats were drenched with different dosages of tannin once daily, that are 25, 50, and 100 times of the amount of an adults＇ clinical dosage-30 g/60 kg body weight, respectively. It was successively ig administered for 90 d, and the recovery period was 15 d. The rats＇ blood samples were taken on the dau 60, 90, and 105, respectively for the blood biochemical parameters examination. Results： Compared the experimental groups with the control group, the medicine had some effects on rat serum in 60 d, ALT of high-dose group was significantly increased （P〈0. 01） and medium dose group elevated （P〈0. 05）; ALP medium and small-dose groups were lower （P〈0. 05）; TG of high-dose group was increased （P〈0.05）; All TBIL were significantly decreased （P〈0.01）, ALT and GGT of high-dose groups in rat serum by ig administration for 90 d were increased （P 〈 0.05）. Conclusion： Tannin in P. multiflorum could make rat liver damaged when drenched with long-term and large quantity dosages, the medium dose damages rat liver shortly, and the small dose does no significant damage. Meanwhile all of them could be restored after the withdrawal of tannin in P. multiflorum.