期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血管紧张素转换酶抑制剂抗肿瘤作用的研究进展 被引量：2

原文传递
导出
摘要 血管紧张素转换酶抑制剂 （ angiotensin-converting enzyme inhibitor, ACEI） 是目前广泛应用的降压药物，在临床应用过程中，陆续发现其有多种独特的治疗作用，如对心力衰竭患者的抗左心室重构作用、对蒽环类药物心肌毒性的保护作用、对慢性肾功能不全患者维持肾功能的作用。ACEI不良反应较少，主要包括干咳（发生率5％～20％）、低血压、高钾血症、肾功能恶化。
作者 相同玲
机构地区 辽宁省丹东市第一医院药剂科
出处 《中国医师进修杂志》 2010年第10期74-76,共3页 Chinese Journal of Postgraduates of Medicine
关键词 血管紧张素转换酶抑制剂 抗肿瘤作用 慢性肾功能不全 心力衰竭患者 临床应用 左心室重构 蒽环类药物 肾功能恶化
分类号 R9 [医药卫生—药学]
  • 相关文献

参考文献18

  • 1Ronquist G, Rodr I guez LA, Ruig 6 mez A,et al. Association between captopril, other antihypertensive drugs and risk of prostate cancer. Prostate, 2004,58( 1 ) : 50-56.
  • 2Koh wP, Yuan JM, Sun Cl.,et al. Angiotensin 1-converting enzyme (ACE) gene polymorphism and breast cancer risk among Chinese women in Singapore. Cancer Res, 2003,63( 3 ) : 573-578.
  • 3Gonz a lez-Zuloeta Ladd AM, Arias V a squez A, Sayed- Tabatabaei FA,et al. Angiotensin-converting enzyme gene insertion/deletion polymorphism and breast cancer risk. Cancer Epidemiol Biomarkers Prey, 2005,14(9) : 2143-2146.
  • 4Yoshiji H, Yoshii J, lkenaka Y, et al. Inhibition of reninangiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats. J Hepatol, 2002,37 (1): 22-30.
  • 5杜宏,唐政.血管紧张素受体两种亚型的矛盾与统一[J].医学研究生学报,2006,19(8):757-760. 被引量：4
  • 6Yasumaru M, Tsuji S, Tsujii M,et al. Inhibition of angiotensin Ⅱ activity enhanced the antitumor effect of cyclooxygenase-2 inhibitors via insulin-like growth factor I receptor pathway. Cancer Res, 2003,63 (20) : 6726-6734.
  • 7lno K, Uehara C, Kikkawa F,et al. Enhancement of aminopeptidase A expression during angiotensin Ⅱ-induced choriacarcinoma cell proliferation through ATI receptor involving protein kinase C- and mitogen-activated protein kinase-dependent signaling pathway. J Clin Endocrinol Metab, 2003,88(8) : 3973-3982.
  • 8Amaya K, Ohta T, Kitagawa H,et al. Angiotensin Ⅱ activates MAP kinase and NF-kappaB through angiotensin Ⅱ type Ⅰ receptor in human pancreatic cancer cells. Int J Oncol, 2004,25 (4) : 849-856.
  • 9Ishimatsu S, Itakura A, Okada M,et al. Angiotensin Ⅱ augmented migration and invassion of choriocarcinoma cells involves PI3K activation through the AT1 receptor. Placenta, 2006,27(6/7) :587- 591.
  • 10Ohashi H, Takagi H, Oh H,et al. Phosphatidyli nositol 3- kinase/Akt regulates angiotensin II-induced inhibition of apoptosis in microvascular endothelial cells by governing survivin expression and suppression of caapase-3 activity. Circ Res, 2004,94 (6) : 785- 793.

二级参考文献65

  • 1夏正坤,祁建胜,刘光陵.血管紧张素Ⅱ受体拮抗剂在IgA肾病中的临床应用[J].医学研究生学报,2005,18(5):451-453. 被引量：5
  • 2Ziyadeh FN, Sharma K, Chen Y, et al. Glycated albumin stimulates fibronectin gene expression in glomerular mesangial cells : Involement of the TGF-β system [ J ]. Kidney Int, 1998,53 (3) :631-638.
  • 3Wehbi GJ. Early streptozocin-diabetes mellitus downregulates rats AT2 receptor[J]. Am J Physiol, 2001,280(2) :F254-F265.
  • 4Allen AM, Zhuo J, Mendelsohn FA. Localization and function of angiotensin AT1 receptor[ J]. Am J Hypertens, 2000,13 ( 1 ) :31 S-38S.
  • 5Muller DN, Dechend R, Mervaala EM, et al. NF-kappa B inhibition ameliorates angiotensin Ⅱ induced inflammatory damage in rats [ J ]. Hypertension, 2000,35 ( 1 ) : 193-201.
  • 6Gomez GD, Largo R, Tejera N, et al. Activation of NF-κB in tubular epithelial cells of rats with intense proteinuria: Role of Angiotensin Ⅱ and Endothelin-1 [J]. Hypertension, 2001, 37(4) :1171-1178.
  • 7Kambayashi Y, Bardhan S, Takahashi K, et al. Molecular cloning of a novel angiotensin Ⅱ receptor isoform involved in phosphotyrosine phosphatase inhibition [ J ]. J Biol Chem, 1993,268(10) :24543-24546.
  • 8Yamada H, Horiuchi M, Akishita M, et al. Regulation if vascular development and differentiation by angiotensin Ⅱ type 2 receptor[J]. Hypertension, 1997, 30(3) :470-475.
  • 9Hayashida W, Horiuchi M, Dzau VJ. Intracellular third loop domain of angiotensin Ⅱ type-2 receptor-Role in mediating signal transduction and cellular function[J]. J Biol Chem, 1996, 271(8) :21985-21992.
  • 10Lehtonen JYA, Horiuchi M, Daviet L, et al. Activation of the de novo biosynthesis of sphingolipids mediates angiotensin Ⅱ type 2 receptor-induced apoptosis [ J ]. J Biol Chem, 1999, 274 (4) :16901-16906.

共引文献8

同被引文献16

引证文献2

二级引证文献5

中国医师进修杂志
2010年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部