摘要
目的:研究浙贝母对甲状腺功能亢进(甲亢)模型鼠的保护作用。方法:采用甲状腺素复制甲亢模型鼠,并观察浙贝母对甲亢模型鼠三碘甲状腺素原氨酸(T3)、四碘甲状腺素原氨酸(T4)、环磷酸腺苷(cAMP)、环磷酸鸟苷(cGMP)以及耐缺氧能力的影响。结果:浙贝母具有显著降低甲亢模型大鼠T3、T4、cAMP的作用,且能显著提高甲亢模型小鼠的耐缺氧能力。结论:浙贝母具有较好对抗甲亢的作用。
OBJECTIVE：To study the protection effect of Fritillaria thunbergii against hyperthyroidism in rats and mice. MET-HODS：Hyperthyroidism rats and mice were induced with thyrine. The effect of F. Thunbergii on T3,T4,cAMP,cGMP and hypoxia tolerance were observed. RESULTS：F. Thunbergii can decrease T3,T4 and cAMP of rats significantly. It also can increase the abi-lity of hypoxia tolerance of mice significantly. CONCLUSION：F. Thunbergii has sound effect on hyperthyroidism.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第15期1362-1363,共2页
China Pharmacy
关键词
甲状腺功能亢进
浙贝母
实验研究
Hyperthyroidism
Fritillaria thunbergii
Experimental study
