耐亚胺培南铜绿假单胞菌的耐药性分析

Analysis of Drug-resistance in Imipenem-resistant Pseudomonas aeruginosa

目的探讨医院耐亚胺培南铜绿假单胞菌(IRPA)医院感染的临床现状及耐药性,为临床医师诊断与治疗提供科学依据。方法调查医院2年来IRPA医院感染患者的临床资料;采用K-B法对铜绿假单胞菌(PAE)进行药物敏感试验,并进行统计分析。结果766株PAE中,IRPA占总数的35.1%,药敏试验结果显示,IRPA对常用抗菌药物耐药率明显高于非亚胺培南耐药株。结论医院应重视抗菌药物使用管理,尤其要关注PAE耐药菌株的产生与流行。

OBJECTIVE To investigate the clinical status and drug-resistance in nosocomial infection with imipenemresistant Pseudornonas aeruginosa （IRPA） to provide scientific evidence for clinical diagnosis and treatment. METHODS The clinical data of the patients infected with IRPAE during 2 years were investigated. Antibiotic susceptibility testing in vitro was performed by K-B methods. RESULTS Among 766 P. aeruginosa （PAE） strains, IRPA accounted for 35.1%. The resistance rates of commonly used antibiotics in IRPA were significantly higher than those in non-IRPA strains. CONCLUSIONS Hospital should attach importance to management of antibiotics and pay close attention to the occurrence and prevailing of drug-resistant strains, especially.