鄂州市铜绿假单胞菌的耐药性分析

Drug-resistance of Pseudomonas aeruginosa in Ezhou

目的探讨鄂州地区医院感染铜绿假单胞菌(PAE)的分布及耐药性,为临床医师用药提供指南。方法铜绿假单胞菌的培养与鉴定严格按照《全国临床检验操作规程》进行。药敏试验采用纸片扩散法(K-B法)。结果244株PAE主要分布在重症监护病房(ICU)、呼吸内科、脑外科和胸外科;PAE对碳青酶烯类抗菌药物亚胺培南、美罗培南的敏感率最高,均为84.0%;耐药率≥50.0%的抗菌药物有:复方新诺明(95.5%)、氨曲南(69.3%)、头孢噻肟(68.0%)、庆大霉素(60.7%)、环丙沙星(59.4%)、左氧氟沙星(54.1%)、哌拉西林和头孢吡肟(均50.0%)。结论医院感染PAE的耐药性已非常严重,应加强抗菌药物使用管理,预防耐药菌的传播与医院感染暴发流行。

OBJECTIVE To investigate the flora distribution and drug-resistance in nosocomial infections with Pseudomonas aeruginosa （PAE） to provide the scientific accordance for the clinical use of the antibiotics. METHODS PAE was cultured and identified according to the National Clinical Laboratory Operation Rules. Drug susceptibility testing was performed by K-B methods. RESULTS The 244 strains of PAE were mainly isolated from intensive care unit （ICU）, department of respiratory medicine, department of neurosurgery and department of chest surgery. Drug resistance results of PAN to commonly used antibiotics showed that 84.0% of PAE were susceptible to carbapenem such as imipenem and meropenem with the highest susceptibility. The antibacterials with ≥50. 0K resistance rate were as followed.. SMZ-TMP （95. 5%）, aztreonam （69. 3%）, cefotaxime （68.0%）, gentamicin （60. 7%）, ciprofloxacin （59. 4%）, levofloxacin （54. 1%）, piperacillin （50. 0%） and cefepime （50.0% ）. CONCLUSIONS The drug-resistance status of nosocomial infections due to PAE is very serious in Ezhou. We should strengthen management of antibiotics to prevent spread of resistant strains and outbreak of nosoeomial infections.