1003株鲍氏不动杆菌医院感染的分布与耐药性分析

Distributing Characteristics and Drug Resistance of 1003 strains of Acinetobacter baumannii in Nosocomial Infection

目的了解鲍氏不动杆菌的临床分布及耐药性变迁情况，为有效预防该菌的感染和指导临床用药提供依据。方法对2001～2008年医院临床分离的鲍氏不动杆菌的临床分布及耐药率进行回顾性分析。结果2001～2008年共分离鲍氏不动杆菌1003株，其年检出细菌总数呈逐年上升趋势；分离的鲍氏不动杆菌除对亚胺培南有较高的敏感性外，对其他常用的12种抗菌药物均有较高的耐药性，近年来对环丙沙星、庆大霉素、复方新诺明及妥布霉素耐药率〉70％，对头孢菌素类抗菌药物耐药率均〉50％，且多药耐药及全耐药菌株的检出数量及比率均呈逐年增加趋势。结论动态监测鲍氏不动杆菌的耐药性变迁，有助于指导临床制定最佳治疗方案，并采取有效措施控制鲍氏不动杆菌在医院内的定植和播散，同时尽量减少耐药菌株的产生。

OBJECTIVE To understand the distribution characteristics and drug resistance of Acinetobacterbaumannil （ABA） in clinical specimens, so as to provide reference for rational use of antibiotics in clinic. METHODS Drug resistance and clinical distribution of ABA during from 2001 to 2008 were analyzed and studied retrospectively. RESULTS During the 6 year infection surveillance, 1003 strains of ABA were isolated in our hospital, the annual total number of bacteria showed an upward trend year after year. These strains were susceptible only to imipenem, and the rate of drug-resistance to other antibiotics such as ciprofloxacin, gentamicin, sulfamethoxazole/ trimethoprim and tobramycin were all more than 70%, and to other cephalosporin antibiotics the resistance rate was more than 50% in recent years. Multidrug-resistant and Pandrug-resistant strains increased annually. CONCLUSIONS Dynamic monitoring of A. baumannii resistance changes helps to guide the development of best clinical treatment of infection, and to take effective measures to control the A. baumannii colonization and spread in hospitals, while minimizing the emergence of resistant strains.