传染病医院医院感染病原菌及耐药分析

Nosocomial Pathogens and Drug-resistance in an Infectious Disease Hospital

目的研究传染病医院医院感染的主要病原菌及药敏情况。方法对解放军第302医院2005年12月～2008年12月医院感染的临床资料进行回顾性分析。结果1832例医院感染革兰阴性菌为主，发生率最高为大肠埃希菌，约占所有菌株的31．8％，对多种抗菌药物耐药，其次为肺炎克雷伯菌，占12．3％；革兰阳性菌中表皮葡萄球菌占4．9％，金黄色葡萄球菌占4．0％；真菌中白色假丝酵母菌最常见，占9．9％。结论大肠埃希菌是传染病医院医院感染的主要病原菌，且对多种抗菌药物耐药。

OBJECTIVE To study the nosocomial pathogens and drug-sensitivity in an infectious disease hospital. METHODS Retrospective analysis was conducted on sputum cultivation from patients who were hospitalized from Nov 2005 to Nov 2008 in the 302 hospital of PLA. RESULTS A total of 1832 pathogenic strains were isolated, most of which were Gram-negeative, of which Escherichia coli accounted for 31. 8%. Their multiple durgresistance to anti-microbial agents was serious; Klebsiella pneumoniae accounted for 12. 3%. Among Grampositive bacilli, most of which were Staphylococcus epidermidis and S. aureus, accounted for 4.9% and 4.0%, espeetively; among fungi, most of which were Candida albicans, accounted for 9.9%. CONCLUSIONS E. coli is the main nosoeomial pathogen in an infectious disease hospital, and shows multiple durg-resistanee to antimierobial agents in drug sensitive test.