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妊娠滋养细胞肿瘤的化疗 被引量：5

Chemotherapy for gestational trophoblastic neoplasia
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摘要 由于妊娠滋养细胞肿瘤(GTN)对化疗高度敏感,绒毛膜促性腺激素(HCG)可作为理想的肿瘤标志物,以及应用预后评分可使其治疗达到分层个体化,GTN成为了少数几个能通过化疗而达到治愈的肿瘤之一。文章介绍了近年来有关妊娠滋养细胞肿瘤化疗进展。 Gestational trophoblastic neoplasia（GTN） is one of the few highly curable human tumors with chemotherapy.The successful management of GTN by chemotherapy takes advantage of its intrinsic sensitivity to certain antineoplastic drugs,human chorionic gonadotropin as an optimal tumor marker,and identification of high risk factors that permits individualized treatment.This review discusses the recent advances in the chemotherapy of GTN.
作者 吕卫国
机构地区 浙江大学医学院附属妇产科医院
出处 《中国实用妇科与产科杂志》 CAS CSCD 北大核心 2010年第3期182-184,共3页 Chinese Journal of Practical Gynecology and Obstetrics
关键词 妊娠滋养细胞肿瘤 化疗 gestational trophoblastic neoplasia chemotherapy
分类号 R71 [医药卫生—妇产科学]
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参考文献8

  • 1Savage P, Seckl M,Short D. Practical issues in the management of low-risk gestational trophoblast tumors [J]. J Reprod Med, 2008,53:774-780.
  • 2Chan KK, Huang Y, Tam KF, et al. Single-dose methotrexate regimen in the treatment of low-risk gestational trophoblastic neoplasia [J]. Am J Obstet Gynecol, 2006,195 ( 5 ) : 1282-1285.
  • 3Matsui H,Suzuka K,Yamazawa K. Relapse rate of patients with low-risk gestaional trophoblastic tumor initially treated with single-agent chemotheray [ J ]. Gynecol Oncol, 2005,96 ( 3 ) : 616- 620.
  • 4陈亚侠,沈源明,钱建华,谢幸.采用甲氨蝶呤初次化疗方法对低危妊娠滋养细胞肿瘤疗效及影响因素的分析[J].中华医学杂志,2005,85(30):2109-2112. 被引量：9
  • 5Kim SJ, Bae SN, Kim JH, et al. Effects of multiagent chemotherapy and independent risk factors in the treatment of high-risk GTT-25 years experiences of KRI-TRD [ J ]. Int J Gynaecol Obstet, 1998,60 ( suppl 1 ) : s85-96.
  • 6McNeish IA, Strickland S, Holden L, et al. Low-risk persistent gestational trophoblastic disease: outcome after initial treatment with low-dose methotrexate and folinic acid from 1992 to 2000 [J]. J Clin Oncol,2002,20(7) :1838-1844.
  • 7Powles T, Savage PM, Stebbing J, et al. A comparison of patients with relapsed and chemo-refractory gestational trophoblastic neoplasia [ J ]. Br J Cancer,2007,96 ( 5 ) :732-737.
  • 8Newlands ES, Mulholland P J, Holden L, et al. Etoposide and cisplatin/etoposide, methotrexate, actinomycin ( EMA ) chemotherapy for patients with high-risk gcstational trophoblastic tumors refraetory to EMA/cyelophosphamide and vincristine, and patients presenting with metastatic placental site trophoblastie tumors[J]. J Clin Oncol,2000,18:854-859.

二级参考文献11

  • 1Soper JT, Clarke-Person DL, Berchuck A, et al. 5-day methotrexate for woman with metastatic gestational trophoblastic disease. Gynecol Oncol, 1994,54:76-79.
  • 2Hancock BW,Newlands ES, Berkowitz RS. Gestational trophoblastic disease. New York:Chaman & Hall Medical,1997.
  • 3The FIGO Oncology Committee. FIGO staging for gestational trophoblastic neoplasia. Int J Gynecol Obstet,2002,77:285-287.
  • 4Benedet JL, Bender H, Jones H 3rd, et al. FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology. Int J Gynaecol Obstet, 2000,70:209 -262.
  • 5谢幸.妊娠滋养细胞疾病[A].乐杰.妇产科学:第6版[C].北京:人民卫生出版社,2004.319-329.
  • 6Cirisano FD, Jr, Soper JT. Practical management of gestational trophoblastic disease. Prim Care Update Ob/Gyns, 1999,6:75-81.
  • 7Berkowitz RS, Goldstein DP. Gestational trophoblastic disease. In:Berek JS. Novak' s Gynecology. 13 th ed. Philadelphia: Lippincott Williams & Wilkins,2002. 1353-1373.
  • 8Garret AP, Garner EO,Goldstein DP,et al. Methotrexate and folinic acid as primary therapy for nonmetastatic and low-risk metastatic gestational trophoblastic tumor. J Reprod Med ,2002,47:355-362.
  • 9McNeish IA , Strickland S, Holden L, et al. Low-Risk persistent gestational trophoblastic disease: outcome after initial treatment with low-dose methotrexate and folinic acid from 1992 to 2000. J Clin Oncol,2000,20 : 1838-1844.
  • 10Nevin J, Silcocks P, Hancock B, et al. Guidelines for the stratification of patients recruited to trials of therapy for low-risk gestational trophoblastic tumor. Gynecol Oncol,2000,78:92-96.

共引文献8

同被引文献24

引证文献5

二级引证文献8

中国实用妇科与产科杂志
2010年 第3期

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