化疗对卵巢功能的损伤及药物保护

Medication protect against chemotherapy-induced ovarian injury

化疗是妇科恶性肿瘤主要治疗方法,但化疗药物可损害年轻患者的卵巢功能。临床研究显示促性腺激素释放激素（GnRHa）对卵巢功能有一定保护作用,一般主张在化疗前7~10d使用。其他激素替代治疗、口服避孕药和细胞凋亡抑制剂如1-磷酸-神经鞘氨醇等可能也有保护卵巢功能的作用。

Chemotherapy is important for women with malignant tumors, however, it is harmful for ovarian function. Many reports shown that there were functional protections of the ovary for adolescents or adult patients with malignant tumors during chemotherapy by GnRH analogs, in which it suggested to be used before chemotherapy from 7 to 10 days. Oral contraceptive, sphingolipids-phosphate, and others as the protective agents still need to be study.