埃索美拉唑联合左旋氧氟沙星 阿莫西林治疗幽门螺杆菌相关性十二指肠溃疡

Efficacy of Esomeprazole in Combination with Levofloxacin and Amoxicillin in Treatment of Helicobacter pylori-associated Duodenal Ulcer

目的探讨耐信联合左旋氧氟沙星和阿莫西林治疗幽门螺杆菌(Hp)相关性十二指肠溃疡(DU)的临床疗效。方法收集62例Hp阳性的DU患者,随机分为两组,联合治疗组(n=31)接受耐信、左旋氧氟沙星和阿莫西林治疗,而对照组患者(n=31)仅接受耐信治疗。经过8周治疗后分析DU患者的临床症状改善状况,Hp的根除率,比较十二指肠球部溃疡愈合以及胃窦黏膜炎症分级情况。结果经过8周正规治疗后,联合治疗组患者临床症状(如上腹部疼痛、烧心、上腹不适、嗳气)明显改善,Hp的根除率明显升高(96.8%vs64.5%,P<0.05),溃疡愈合率明显高于对照组(100%vs 80.6%,P<0.05),胃窦黏膜炎症分级亦明显降低(P<0.05)。结论耐信联合左旋氧氟沙星和阿莫西林可有效地控制Hp相关性DU患者的临床症状,促使溃疡愈合,是治疗Hp相关性DU的一种有效方法。

Objective To investigate clinical efficacy of esomeprazole in combination with levofloxacin and amoxicillin in the treatment of Helicobacter pylori（Hp）-associate duodenal ulcer（DU）.Methods Sixty-two patients with Hp-associated DU were randomly classified into two groups.Patients in treatment group（n=31） received esomeprazole in combination with levofloxacin and amoxicillin,whereas patients in control group（n=31） had only esomeprazole.After 8 weeks of treatment,clinical effects,Hp clearance rates,ulcer healing and antrial mucosal inflammation were analyzed in both groups.Results After 8 weeks of treatment,treatment group significantly improved clinical symptoms including epigastric pain,heartburn,abdominal discomfort and eructation,markedly enhanced Hp clearance rates（96.8% vs 64.5%,P0.05） and ulcer healing（100% vs 80.6%,P0.05）,as well as significantly improved antrial mucosal inflammation compared with that of control group（P0.05）.Conclusion Esomeprazole in combination with levofloxacin and amoxicillin is effectively to treat Hp-associated DU and promote ulcer healing.