计算机分析影响胃癌淋巴结转移的因素

Computerized Multivariate Analysis on Factors Influenting Lymph Node Metastasis in Gastric Cancer

目的:回顾性分析影响胃癌淋巴结转移的诸因素,为合理制定根治术式提供理论依据.方法:分析554例胃癌切除术患者的病史、手术记录和病理检测结果资料.应用BMDP软件包计算不同部位淋巴结转移者术后逐年生存率,采用单因素和Logistic回归多因素分析方法探讨胃癌临床病理特点与淋巴结转移的关系.结果:淋巴结转移者和无转移者5年生存率分别为31.04%和90.9%.单因素分析发现,大体类型、分化程度、浸润深度、原发部位及肿瘤大小均与淋巴结转移有关;多因素分析则发现肿瘤浸润深度及肿瘤大小为影响淋巴结转移的独立因素.结论:淋巴结转移是影响胃癌患者预后的重要因素,而胃癌的临床病理特点与淋巴结转移密切相关.

To analyse the factors influenting lymph node metastasis in gastric cancer and to offer a theoretical basis for the planning of a radical operation. Methods: 554 gastric cancer patients undergoing gastrectomy were studied retrospectively in terms of history, operation records and pathological data. The BMDP software package was used to analyse the survival rate of the patients with lymph node metastasis. The relationship between the clinico-pathological characteristics of the tumor and its lymph node metastasis was studied by means of mono-variate and logistic regression multivariate analysis. Results: The 5-year survival rates of patients with and without lymph node metastasis were 31.04% and 90.9% respectively. Mono-variate analysis revealed that gross classification, degree of histologic differentiation, depth of invasion, location of the primary tumor and its diameter were correlated with lymph node metastasis; While by multivariate analysis, the depth of invasion and the diameter of tumor were proved to be independent factors. Conclusions: Lymph node metastasis is one of the most important factors influencing the prognosis of gastric cancer patients, it is closely correlated with many clinico-pathologic features of the tumor.