期刊文献+

胃癌及其癌旁病变中p16、nm23-H_l基因蛋白的表达及意义

Expression of p16 and nm23-H_1 Protein in Gastric Carcinoma
下载PDF
导出
摘要 目的:应用免疫组化方法探讨p16蛋白在胃癌发生中的作用.方法:应用免疫组化方法对57例胃癌切除标本进行p16蛋白和nm23-H_1基因产物的表达检测.结果:57例胃癌中p16蛋白表达阳性率为40/57(70.2%),显著低于癌旁正常胃粘膜(P<0.01).胃癌高分化组的阳性率显著高于低分化组(P<0.05),不同临床分期(UICC分期)及有无淋巴结转移的胃癌病例中,p16蛋白的表达差异无显著性.癌旁胃粘膜肠上皮化生及不典型增生病变中的p16蛋白阳性率介于胃癌及正常胃粘膜之间.肿瘤转移抑制基因nm23-H_1在胃癌的阳性率为41/57(71.9%).不同组织学分级及淋巴结转移的病例中有显著性差异.p16蛋白和nm23-H_1在胃癌的表达呈一定的正相关.结论:本研究认为p16蛋白在胃癌发生中起一定作用. To investigate the expression of p!6 protein in the carcinogenesis of human gastric carcinoma. Methods: The expression of p16 protein and nm23-H1 gene products were studied immunohistochemically in 57 cases of gastric carcinoma. Results: The positive rates of p16 protein were 70.2%(40/57) in gastric carcinoma tissue and 92.9%(53/57) in the normal surrounding tissue(P< 0.01); the positive rate also showed a significant difference in the well and poorly differentiated group(P<0.05); but no difference was found in group of different clinical stage with or without lymph node metastasis. nm23-H1 protein showed a positive rate of 71.9%(41/57) gastric carcinoma, it was related to the differentiation status, but also related to the lymph node metastasis of gastric carcinoma. p16 and nm23-H1 protein expression showed a positive correlationship. Conclusions: p16 protein may play a role in the carcinogenesis of human gastric carcinoma.
出处 《外科理论与实践》 1998年第1期24-26,共3页 Journal of Surgery Concepts & Practice
关键词 胃肿瘤 基因产物 免疫组化 P^16 NM23-H1 Gastric neoplasms Gene products Immunohistochemistry
  • 相关文献

参考文献8

  • 1Kamb A, Gruis NA, Weaver-Feldhaus J, et al. A cell cycle regulator potentially involved in genesis of many tumor types. Science, 1994. 264: 436.
  • 2Huang L, Goodrow TL, Zhang SY, et al. Deletion and mutation analysis of the p16/MTSI tumor suppressor gene in human ductal pancreaticcancer reveals a higher frequency of abnormalities in tumor-derived cell lines than in primary ductal adenocarcinoma. Cancer Res, 1994, 56: 1137.
  • 3杜德利,王万忠,刘宇,范慧.硫酸铝钾暴露抗原免疫组化法检测HPV[J].临床与实验病理学杂志,1997,13(2):182-183. 被引量:6
  • 4Herman TG, Merlo A, Mao L, et al. Inactivation of the CDK2/p16/MTSI gene is freqently associated with aberrant DNA methylation in all common human cancers, Cancer Res, 1995, 55:4525.
  • 5吕有勇,高崇峰,崔建涛,孙梅程,金泉.胃癌中MTS1/p16基因缺失及表达异常的研究[J].中华肿瘤杂志,1996,18(3):189-191. 被引量:88
  • 6Kratzke RA, Greatens TM, Rubins JB, et al. Rb and pl6INK4a expression in resected non-small cell lung tumors. Cancer Res, 1996, 56: 3415.
  • 7Sawan A, Lacu L, Veron M, et al. NDPK/nm23 expression in human breast cancer relation to relapse survival, and other prognostic factors: an immunohistochemical study. J Pathol. 1994. 172: 27.
  • 8张声,叶圣华,林华.p53过表达和nm23低表达与胃癌淋巴结转移关系的探讨[J].中华肿瘤杂志,1995,17(6):418-421. 被引量:30

二级参考文献2

共引文献121

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部