麦普替林治疗癌症患者的抑郁情绪

Maprotiline in Depressive Emotion of the Patients with Cancer

为验证麦普替林对癌症患者抑郁倩绪的疗效．本研究采用双盲对照研究，对55例癌症术后有明显抑郁情绪的患者采用麦普替林50～100mg／日治疗，观察4周。以抑郁自评量表（SDS）及疗效后评量表（CGI）及患者自觉效果判定，评定疗效、不良反应症状量表（TESS），评定不良反应，结果显示实验组SDS减分值、减分率及疗效指数明显高于对照组，自觉显效率96％，对照组别为21％。两组有明显差异，提示麦普替林对癌症患者的抑郁情绪有明显疗效。

In order to prove the curative effect of maprotiline in the depressive emotion of the patients with cancer, this study adopted double- blind control method, treating 55 patients with obvious depressive emotion after carcinectomy using 50~100mg/d maprotiline and bserving for 4 weeks. The curative effect were rated with SDS,CGI and the conscious effect of patienL,and adverse reaction with TESS The results showed that the value and rate of SDS minus and index of curative effect in experimental group were obviously higher than that in the controls;the conscious effectual rate of the experimental was 96% and the controls 21 %. There was significant difference between the 2 groups,it suggested that maprotiline had evident effect on the depressive emotion of the patient with cancer.