脂肪细胞因子在非酒精性脂肪性肝病中的作用

Action of Adipocytokines in Nonalcoholic Fatty Liver Disease

目的:探讨脂肪细胞因子瘦素、脂联素在非酒精性脂肪性肝病发病及其发展中的作用。方法:NAFLD患者60例与健康组60例相对照,ELISA法测定血清瘦素、脂联素水平。结果:NAFLD组与对照组相比,血清瘦素水平明显高于对照组(P<0.01),脂联素水平明显低于对照组(P<0.01)。结论:NAFLD患者血清瘦素水平升高,血清脂联素水平降低,这两种细胞因子均与胰岛素抵抗相关。

Objective：To explore the action of adipocytokines leptin and adiponectin in outbreak and development nonalcoholic fatty liver disease（NAFLD）.Methods：The level of serum leptin and adiponectin was determined by ELISA in 60 patients with NAFLD and compared with 60 health cases as control.Results：The level of serum leptin was more higher in NAFLD group than in control group（P〈0.01）.The level of serum adiponectin was more lower in NAFLD group than in control group（P〈0.01）.Conclusion：The level of serum leptin increases and the level of serum adiponectin decreases in patients with NAFLD.All of the two kinds cytokine relates with the insulin resistance.