MRI在甲状腺相关眼病分级和分期的应用

Application of MRI in severity grading and activity staging in thyroid associated ophthalmopathy

评价MRI对甲状腺相关眼病（TAO）临床严重度分级和活动性分期评价的影响。结果显示NOSPECS 2级和3级病例MRI均发现了眼外肌受累的证据。MRI对眼外肌受累显示的阳性率明显高于NOSPECS评分（Х^2=19．37，P=0．000）。MRI比临床活动性评分（CAS）判断“活动期”有更高敏感度、特异度、准确度（100％对95．7％、88．2％对35．3％、96．9％对79．7％）。提示MRI增加了早期不典型4级TAO的发现率，压脂T2WI信号可作为TAO活动分期的判断指标。

The influence of MRI on severity grading and activity staging in thyroid associated ophthalmopathy （TAO） was evaluated. The results showed that MRI had a higher detection rate in abnormal extraocular muscle than NOSPECS scores（Х^2 = 19.37,P = 0. 000）. MRI had higher sensitivity, specificity, and accuracy in detection of active TAO than clinical activity score （ 100% vs 95.7% , 88.2% vs 35.3% , 96.9% vs 79.7%, respectively）. Therefore, MRI improves early detection of atypical grade 4 cases. Signal intensity elevation in adipose suppressed T2WI is helpful to define active stage.