摘要
观察环孢素A对糖尿病大鼠心肌基质金属蛋白酶（MMP）表达的影响。发现糖尿病大鼠心肌MMP-2、MMP-9 mRNA和蛋白表达均明显上凋（P〈0．05或P〈0．01），环孢素A可下调上述异常表达（P〈0．05或P〈0．01）。提示环孢素A可能具有减轻糖尿病心肌细胞损伤的作用。
The effects of eyclosporine A on matrix metalloproteinases（MMP）-2 and -9 expressions in the cardiac muscle of streptozocin-induced diabetic rats were investigated. The expressions of MMP-2 and MMP-9 mRNA and proteins in the cardiac muscle of diabetic rats were significantly upregulated, which could be decreased by cyclosporine A（P〈0.05 or P〈0. 01 ）. The results suggest that cyclosporine A may effectively ameliorate the injuries of diabetic cardiomyopathy.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2010年第3期238-240,共3页
Chinese Journal of Endocrinology and Metabolism
基金
天津市科技发展计划项目（05YFSYSF01200）
天津市卫生局科技基金（05KYZ82）
关键词
糖尿病
糖尿病心肌病
基质金属蛋白酶
环孢素A
Diabetes mellitus
Diabetic cardiomyopathy
Matrix metalloproteinases
Cyclosporine A
