中药诱导骨髓间充质干细胞向神经样细胞分化的研究进展

Research progress of bone marrow mesenchymal stem cells differentiation into nerver-like cells induced by traditional Chinese medicine

骨髓间充质干细胞具有较强的自我复制和多向分化能力,近几年发现在一定的条件下,能够诱导分化为神经细胞。由于其具有取材方便,回植后不会发生免疫排斥反应,体外基因转染率高并能稳定高效表达外源基因等优点,将为神经系统疾病的治疗提供新的思路。本文阐述中药诱导骨髓间充质干细胞向神经样细胞分化方面的研究进展,探讨中医基础理论指导下的研究思路。

Bone marrow mesenchymal stem cells （MSCs） have active abilities of self replication and multidifferentiation. In recent years,a lot of studies have proved that MSCs can be induced and differentiated into never like cells under certain conditions. Because of some advaced characteristics including sampling convenience,no immune rejection,high transfection rate and stable exogenous gene expression,MSCs will provide new way in treating disease of nervous system. In this article,the research progress of bone marrow mesenchymal stem cells differentiation into nerver like cells induced by Traditional Chinese Medicine shall be discussed,and explore the research thinking guided by basis theory of TCM.