内源性神经干细胞与脊髓损伤的研究进展

Endogenous Neural Stem Cells in Spinal Cord Injury(review)

利用内源性神经干细胞治疗脊髓损伤是目前脊髓损伤研究的新热点。正常成年脊髓靠近中央管的室管膜与室管膜下区和白质实质存在内源性神经干细胞,脊髓损伤后内源性神经干细胞被活化并增殖和迁移到损伤区。大部分内源性神经干细胞分化成星型胶质细胞和有助于再髓鞘化的少突胶质细胞,而不是神经元。对内源性神经干细胞的定向分化调控是治疗脊髓损伤的关键问题也是目前尚未解决的难题。

Recent advances in endogenous neural stem cells have made regeneration-based therapies feasible as therapeutic strategies for spinal cord injuries. Endogenous neural stem cells of the intact adult spinal cord reside not only in the ependymal layer of the central canal but also in the parenchyma,followed by responses of the activation and migration in the injured spinal cord. The most endogenous neural stem cells differentiate scar forming astrocytes and myelin-forming oligodendrocytes,but not neurogenic neurons. Thus the knowledge in intrinsic program of endogenous neural stem cells differentiation is obviously difficult and crucial for the recovery of spinal cord injury in the present.