间变性室管膜瘤临床病理观察

Clinicopathologic study of anaplastic ependymoma

目的:探讨间变性室管膜瘤的临床病理特点、鉴别诊断及生物学特征。方法:对3例间变性室管膜瘤大体与镜下形态进行分析并复习临床资料及相关文献。结果:间变性室管膜瘤好发于脑室系统,临床表现大多有颅内压升高症状。组织形态学诊断可依据细胞密度增高,核分裂活跃,围绕血管的假菊形团及灶区坏死等特征。免疫组化标记表达GFAP。随访:2例死亡,1例术后复发。结论:间变性室管膜瘤生长迅速,预后差,生物学行为应界定为恶性。

Objective：To investigate the clinicopathologic features,differential diagnosis and biological characteristics of anaplastic ependymoma.Methods： Three cases of anaplastic ependymoma,clinical and pathologic data were reported and the related literature were reviewed.Results： The tumour was commonly found in the ventricles of the brain system,most clinical manifestations were intracranial hypertension.The tectology diagnosis may advance based on the cell density,the nuclear fission is active,blood vessel＇s false chrysanthemum shape group and stove area necrosis.Immunohistochemical staining for GFAP was positive.Conclusion： Anaplastic ependymoma is with rapid growth,poor clinical course,biological behavior should be defined as malignant.