OPN在乳腺癌复发转移中的意义

Expression of OPN in recurrent and metastatic breast cancer

目的:初步研究在乳腺癌中OPN的表达及其对乳腺癌复发转移的影响。探索OPN与ER、PR、C-erbB-2等多个乳腺癌相关因子及临床病理参数的关系。方法:选取中南大学湘雅医院乳腺科1996年至2001年间手术、获随访的乳腺癌患者70例,分为5年内出现复发转移组40例(A组)和无瘤生存组30例(B组),另选取纤维瘤组织10例(C组)及正常乳腺组织15例(D组)。应用免疫组化法检测OPN的表达情况。结果:OPN在70例乳腺癌中阳性表达率72.86%,与C组、D组OPN表达存在显著性差别(P<0.001)。OPN与ER、PR、C-erbB-2及年龄、腋淋巴结转移、TNM分期等临床病理因素无相关性(P>0.05);与p53关系不确定。A、B组间OPN表达存在显著性差别。结论:OPN与乳腺癌的预后有关,高表达的患者易复发转移。

Objective：To explore the expression of OPN in recurrence and metastasis of breast cancer.To investigate the relationship between OPN and ER,PR,C-erbB-2,p53 and the clinical pathological factors in breast cancer.Methods： Forty cases with recurrence or metastasis in 5 years（Group A）,30 cases without recurrence or metastasis in 5 years（Group B）,and 10 cases with breast fibroma（Group C）and 15 cases with normal breast tissue（Group D）,which were surgically resected in the Department of Breast Surgery,XiangYa Hospital,from 1996 to 2001,were included in this study.The expressions of OPN were studied in four groups by immunohistochemical staining technique.All statistics analysis was used by SPSS 11.5 for window.Results：The expression positive rate of OPN was 72.86%（51/70） in breast cancer,which was different from Group C and Group D.OPN positive expression was not correlated with that of ER,PR,C-erbB-2,p53,and clinical pathological factors such as age,pathological,neoadjuvant chemotherapy（P〉0.05）.However OPN positive expression was correlated with p53.There was statistically significant difference on expression of OPN between Group A and B.Conclusion： OPN may be correlated with the development of breast carcinoma and associated with the prognosis of breast cancer.