原发性胆囊癌中Nrf2的表达及意义

The expression and significance of Nrf2 in primary gallbladder

目的:探讨nuclear factor-erythroid 2 p45-related factor 2(Nrf2)在原发性胆囊癌中的表达及其与病理指标的关系。方法:应用免疫组化SP法检测59例原发性胆囊癌中Nrf2的表达。结果:Nrf2呈散在分布的淡黄色或棕褐色颗粒,主要定位于细胞核中,散见于细胞浆中,强阳性表达率分别为72.8%。随着转移程度、Nevin分级以及病理分级的增加,强阳性表达率增加,且具有统计学差异(P<0.05)。Nrf2表达与性别、年龄相关性不明显(P>0.05)。结论:Nrf2的高表达参与了原发性胆囊的发生发展,Nrf2与原发性胆囊癌的分化、转移有关。

Objective：To study the expression of nuclear factor-erythroid 2 p45-related factor 2（Nrf2） and its correlation with clinicopathological parameters in primary gallbladder cancer.Methods：Immunohistochemical SP method was used to detect the expression of Nrf2 in 59 cases of primary gallbladder cancer.Results：The main location of Nrf2 was nuclear,and the strong positive expression rate was 72.8%.The expression of Nrf2 was closely correlated with the metastasis,Nevin staging,and differentiation（P〈0.05）,but showed no statistical associated with sex and age.Conclusion：Nrf2 may play important role in primary gallbladder cancer oncogenesis.The high expression of Nrf2 is related to the differentiation and metastasis of primary gallbladder cancer.