伴有髓系分化抗原表达的神经母细胞瘤骨髓转移1例并文献复习

A case report of neuroblastoma bone marrow metastasis with myeloid antigen expression and review of literature

目的:报道伴有髓系抗原表达的神经母细胞瘤骨髓转移患儿1例,并进行文献复习。方法:取患者骨髓液进行细胞形态学分析及流式细胞术检测细胞分化抗原。结果:该患者骨髓形态学考虑为神经母细胞瘤髓内转移,经流式细胞术分析异常细胞同时表达髓系分化抗原CD13、CD15和CD11b,结合影像学检查确诊为神经母细胞瘤(Ⅳ期)。结论:复习相关文献并结合本例报道发现神经母细胞瘤细胞和造血细胞拥有一些相同的抗原决定簇,可伴有髓系及淋巴系分化抗原的表达,但其在神经母细胞瘤的分化程度、临床分期、疗效及预后判断上的作用尚需进一步研究。

Objective：To report one case of neuroblastoma bone marrow metastasis with myeloid antigen expression and review literature.Methods：Bone marrow sample was collected to perform morphological and cytochemical examination,and analyze cluster of differentiation by flow cytometry.Results：According to morphological and cytochemical test,the child was considered as neuroblastoma bone marrow metastasis,flow cytometry showed abnormal cells both expressed myeloid antigen CD13,CD15 and CD11b,combined with the examination of imageology,the child was diagnosed as neuroblastoma（Ⅳ stage） at last.Conclusion：Neuroblastoma cells and hematopoietic cells had the same antigen determinant,the cells can express both myeloid and lymphoid antigen.However,its contribution to the differentiation,clinical stage,curative effect and prognosis of neuroblastoma would be needed for more investigation.