选择性雌激素受体调节剂

Selective Estrogen Receptor Modulators

雌激素替代疗法（estrogen replacement therapy，ERT）是治疗绝经后综合征的首选治疗方案，但是长期应用导致子宫内膜增生、乳腺癌等。选择性雌激素受体调节剂主要通过ER亚型、共调节子、靶启动子、雌激素受体相关受体等机制实现其组织选择性，在发挥骨骼、心血管保护作用的同时，减少了对乳腺及生殖系统的副作用。目前，选择性雌激素受体调节剂的种类、作用的组织特异性及其临床应用在医学界引起广泛关注，具有广阔的发展前景。

Estrogen replacement therapy （ERT） is the first choice to treat postmenopausal syndromes. However, long-term application will lead to endometrial hyperplasia, breast cancer, and so on. Studies have shown that selective estrogen receptor modulators （SERMs） can achieve their tissue-selective advantages mainly through ER subtypes, comodulators, target promoters, estrogen receptor-related receptors and other mechanisms. They have a protective effect on bone and cardiovascular system, and reduce side effects on breast and reproductive system. Currently, tissue-specificity, mechanism and clinical research applications of various SERM categories are attracting concems of medical profession and possessing broad clinical perspectives.