CMTM2在男性生殖系统中的作用

Function of CMTM2 in Male Reproductive System

CMTM2是首次发现的基因超家族CMTM（CKLF—like MARVEL transmembrance domain containing）的成员，位于染色体16q22．1。大多数CMTM成员在睾丸组织中均有较高表达。前期体外实验研究表明CMTM2在睾丸组织中高度表达，并主要位于精原细胞的细胞质和曲细精管周围液中；在LNCaP细胞中，CMTM2能够加强配体介导的雄激素受体（androgen receptor，AR）的转录；CMTM2在不育患者睾丸组织中具有明显差异表达，其基因和蛋白表达量随着不育程度的加深而减少。CMTM2与它上游的CMTM1、下游的9紧密连接，它们之间可能相互作用发挥作用。

CMTM2 is a member of CKLF-like MARVEL transmembrane domain containing members （CMTM） , a novel gene firstly cloned and identified by Peking University Center for Human Disease Genomics, which maps to chromosome 16q22. 1. Almost all members of CMTM are highly expressed in testis. As reported by previous in vitro studies, CMTM2 is highly expressed in testis tissue and mainly exists in the cytoplasm of spermatogonia and the seminiferous tubular fluid. In LNCaP cells, CMTM2 enhances ligand-mediated transaetivation of androgen receptor. As detected in the testis tissues of spermatogenesis defects patients, CMTM2-positive cell numbers and mRNA level are decreased significantly with the aggravation of spermatogenesis defect. Especially, CMTM2 is tightly linked to upstream CMTM1 and downstream CMTM3 on chromosome 16. They may interact with each other to play important roles in male reproductive system.