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大肠癌microRNA与DNA甲基化修饰相互调控的研究进展 被引量：6

Reciprocal regulation between microRNAs and DNA methylation in colorectal cancer
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摘要 microRNA(miRNA)及DNA的甲基化修饰都属于表观遗传学的重要内容,两者在肿瘤的发生发展中起着重要的作用.目前发现,microRNA与DNA甲基化之间存在着复杂的相互调控机制.本文将就两者在大肠癌中相互作用的研究进展进行综述,旨在为大肠癌的研究提供新的思路. The research on the regulation of microRNAs （miRNAs） and DNA methylation belongs to the scope of epigenetics.Both microRNAs （miRNAs） and DNA methylation play an important role in the development and progression of human cancers.Recently,it has been demonstrated that there exist complex reciprocal regulatory mechanisms between microRNAs and DNA methylation.In this paper,we will give a review of the recent advances in understanding such reciprocal regulation in colorectal cancer,with an aim to offer new insight into the diagnosis and treatment of the disease.
作者 王峰 秦环龙
机构地区 上海交通大学附属第六人民医院
出处 《世界华人消化杂志》 CAS 北大核心 2010年第8期808-814,共7页 World Chinese Journal of Digestology
基金 上海市科委基金资助项目 No.07DZ19505~~
关键词 大肠肿瘤 MIRNA DNA甲基化 表观遗传学 Colorectal cancer MicroRNA DNA methylation Epigenetics
分类号 R735.34 [医药卫生—肿瘤]
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参考文献46

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二级参考文献74

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共引文献1

同被引文献78

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引证文献6

二级引证文献20

世界华人消化杂志
2010年 第8期

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