胃食管反流病患者生活质量调查187例

Quality of life in patients with gastroesophageal reflux disease:an analysis of 187 cases

目的:调查消化门诊人群胃食管反流病(gastroesophageal reflux disease,GERD)生活质量状况.方法:针对安徽铜陵三家市级医院2008-06/08消化内科门诊连续就诊人群,根据国内通用的GERD临床诊断标准(RDQ总积分≥12分)和洛杉矶反流性食管炎(RE)内镜诊断标准进行GERD调查和诊断.采用中文版SF-36生存质量量表进行GERD患者生活质量状况地评估.所有调查资料使用Epi Data3.0软件建立数据库,利用SPSS13.0做统计学分析.根据数据的分布特征,分别采用χ2检验、非参数检验、两样本t检验.结果:三家市级医院消化内科门诊7352例连续就诊患者中共调查诊断出GERD199例.187例GERD患者实际参与了生活质量状况的调查,选取了374例同年龄同性别的正常健康人群进行了病例对照研究.结果显示,GERD病例组8个纬度生活质量评分、SF-36量表总分均明显低于健康对照组,有显著性差异(P<0.05).非糜烂性反流病(nonerosive reflux disease,NERD)组7个纬度生活质量评分、SF-36量表总分均明显低于反流性食管炎(reflux esophagitis,RE)组患者,有显著性差异(P<0.05).无论NERD或RE组女性患者生活质量量表总分均明显低于男性,有显著性差异(P<0.05).结论:GERD患者生活质量较正常健康人群明显下降;在NERD、女性患者中更为突出.精神心理因素可能在GERD发病中起到一定作用.

AIM：To analyze the quality of life in patients with gastroesophageal reflux disease （GERD） attending the gastroenterology outpatient clinics of three hospitals in Tongling,Anhui Province.METHODS：GERD patients were identified from consecutive patients attending the gastroenterology outpatient clinics of three hospitals in Tongling,Anhui Province from June 2008 to August 2008 according to the clinical diagnosticcriteria of GERD （RDQ score ≥ 12） by using the validated Chinese version Reflux Disease Questionnaire （RDQ） and the Los Angeles Classification for diagnosis and grading of reflux esophagitis （RE）.Each GERD patient was matched to two healthy subjects.The impact of GERD on the quality of life in these subjects was evaluated using the Chinese version of the Short Form-36 （SF-36） survey scale.The survey data were used to create a database with the Epi Data 3.0 program.Statistical analysis was performed using the SPSS 13.0 software package.RESULTS：A total of 199 GERD patients were identified from 7 352 consecutive outpatients,of which 187 patients participated in the survey.The quality of life score （SF-36） was significantly lower in GERD patients than in healthy controls,in nonerosive reflux disease （NERD） patients than in RE patients,and in female GERD patients than in male GERD patients.CONCLUSION：The quality of life declines obviously in NERD patients and female GERD patients when compared with RE patients and male GERD patients,respectively.Psychological factors may play an important role in the development of GERD.