自体变异会导致肝功异常吗?

Will short-term variability induce abnormal liver function results?

肝功检测是日常体检的一项重要指标。在肝功检测中,转氨酶或胆红素检测异常的无症状人群在进行复查时,30%的检测结果却在正常范围内。有研究者认为,自体变异可能导致肝功检测结果的较大波动。因此,有必要在临床上对肝功异常的无症状人群再进行常规复查。本文对自体变异在肝功检测中的临床意义进行了评述。

Liver tests are considered as part of a screening examination or general work-up. If retested, more than 30% of asymptomatic patients with elevated AST, ALT, or bilirubin levels would be reclassified as normal. Clinicians should be aware of the high intra-individual variability in common liver tests, and practice guidelines should explicitly recommend retesting of asymptomatic individuals with abnormal liver test results. Here we comment on the clinical implications of variability in liver function test results.