微生物生态系统代谢网络研究进展

Advances in microbial eco-systems metabolic network study—A review

微生物生态系统代谢网络是自然生态系统中微生物遗传分子发挥功能作用的主要形式。本文通过全面介绍微生物生态系统代谢网络的特点及其研究的重要意义,综述了基于共培养技术、免培养高通量技术和计算生物学模拟技术的微生物生态系统代谢网络研究进展和所取得的主要发现,以及近年来快速发展的微生物生态系统代谢网络研究技术和方法体系。在此基础上,提出目前微生物生态系统代谢网络研究中存在的主要问题和重点研究方向,并对其在环境污染治理和资源化利用方面的应用潜力进行了展望。

Microbial eco-systems metabolic networks（MEMNs） are ubiquitous in nature and are the major drivers of biosphere processes.Here we try to define MEMNs and describe their significances in microbial ecology studies.We also review recent progresses and approaches of MEMNs including highlights of the major discoveries in these studies based on mixed-cultures,high-throughput sequencing and microarray data,computational approaches,and metabolic reconstruction.In addition,we discuss the potential shortcomings of current approaches and propose that the time is ripe to study the energy-based microbial metabolic networks in bioremediation systems,especially under the anaerobic conditions,which will reclaim the wastes to resources.