河南省郑州市成年人血糖异常分布与慢性肾脏病的流行病学研究

Epidemiology investigation on pathoglycemia distribution and chronic kidney disease of adults in Zhengzhou city, Henan province

目的了解郑州市区居民血糖异常分布情况，探讨血糖异常分布与慢性肾脏病的关系。方法从2007年“郑州市成年人慢性肾脏病（CKD）及其危险因素流行病学调查”资料中，取有完整资料的1593人（男性659人，女934人）列入本次研究，根据相关疾病诊断标准对资料进行分析。结果郑州市≥20岁居民空腹血糖异常及糖尿病粗患病率分别为30．26％和6．15％，标化患病率为30．76％和6．20％，男性血糖异常患病率高于女性（r=8．040，P=0．005）。按年龄分组后，空腹血糖异常患病率随年龄增长而增加（r=5．571，P=0．018）。该人群中蛋白尿、血尿、估算肾小球滤过率（eGFR）下降和CKD总体患病率分别为5．64％、6．32％、1．59％和11．51％，其中糖尿病组的白蛋白尿及CKD患病率较高，分别为19．39％和28．57％，显著高于空腹血糖正常组和异常组（P〈0．05），且随着病程的延长而升高（r=37．263，P〈0．01）。结论郑州市20岁以上人群血糖异常、糖尿病具有较高的患病率，为30．76％和6．20％，且与CKD患病率有一定关系。

Objective To analyze the distribution of adults pathoglycemia in Zhengzhou urban area and its relation to chronic kidney disease. Methods Data were gathered from the survey of chronic kidney disease and its risk factors of Zhengzhou adults. A total of 1593 subjects （men 659, women 934） with complete data were enrolled in this study. Pathoglycemia and CKD were diagnosed according to associated definition. Results The crude prevalence of pathoglycemia and diabetes mellitus was 30.26% and 6.15% respectively, while the standardized rate was 30.76% and 6.20%. Men had higher prevalence of pathoglyeemia than women （34.14% vs 27.52%,x2=8.040, P = 0.005）, and the prevalence of pathoglycemia was increased with age （x2=5.571, P=0.018）. The prevalence of albuminuria, hematuria, reduced eGFR and CKD was 5.64%, 6.3%, 1.59% and 11.51% respectively after the adjustment of age and gender component. The subjects with pathoglycemia or diabetes mellitus had higher prevalence of albuminuria and CKD （P〈0.05）, which both increased with the course of disease x2=37.263, P〈0.01）. Conclusions Prevalence of pathoglycemia and diabetes mellitus is quite high in adults of Zhengzhou city, whose standardized rate is 30.76% and 6.20% respectively. Pathoglycemia and diabetes mellitus areassociated with the prevalence of CKD.