遗忘型轻度认知障碍内隐记忆启动效应的研究

The study on implicit memory in patients with amnestic mild cognitive impairment

目的探讨遗忘型轻度认知障碍患者(aMCI)内隐记忆概念性启动和知觉性启动损害的特征。方法采用分类产生和图片辨别对35例aMCI患者和35名正常老年人的内隐记忆(概念性启动和知觉性启动)进行测试,同时进行外显记忆(即刻回忆、延时回忆、延时再认)和其他神经心理学背景测试,并进行组间比较和分析。结果与正常老年组相比,aMCI患者组即刻回忆、延时回忆、延时再认、概念性启动成绩均差于正常对照组(P<0.01)。两组在知觉性启动成绩差异无统计学意义(P>0.05)。患者组概念性启动成绩与词汇流畅性成绩呈正相关(r=0.74,P<0.01)。结论aMCI患者外显记忆及内隐记忆的概念性启动存在损害,且其概念性启动损害可能与其额叶功能减退存在一定的相关性。

Objective To investigate the characteristics of memory impairment in patients with amnestic mild cognitive impairment（aMCI）.Methods Thirty-five patients with aMCI and 35 healthy adults matched with age and education level were administered with a neuropsychological battery of tests including conception and perception implicit priming tasks（category exemplar,picture identification）,as well as explicit memory tasks（immediate recall,delay recall,delay recognition）.Results Compared with healthy elders,patients with aMCI were impaired in the conception implicit priming task（t=-4.33,P0.01）,as well as in explicit memory（immediate recall,t=6.40,P0.01;delay recall,t=9.29,P0.01;delay recognition,t=7.65,P0.01）,but not in perception implicit priming task（t=-0.78,P0.05）.The conception implicit priming is positively correlated with verbal fluency（r=0.74,P0.01）.Conclusions The present results indicate that patients with aMCI are impaired in both explicit memory and conception implicit priming.The conception implicit priming impairment in aMCI may be related to their frontal lobe dysfunction.