摘要
Aneuploidy （wrong numbers of chromosomes） is a hallmark of cancer cells and arises from chromosome missegregation in mitosis. To prevent aneuploidy, cells employ surveillance systems to monitor mitosis. The spindle checkpoint （also known as the mitotic checkpoint） is one such surveillance system conserved from yeast to man [1, 2]. During each. mitosis, this check- point detects aberrant kinetochore- microtubule attachments, inhibits the anaphase-promoting complex or cyclosome （APC/C）, stabilizes cyclin B 1 and securin, and delays anaphase onset until all sister chromatids reach proper microtubule attachment.
