骨形态发生蛋白2和成纤维细胞生长因子2在骨组织工程中的应用

Application of bone morphogenetic protein-2 and fibroblast growth factor-2 in bone tissue engineering

背景:1995年Crane GM系统提出了骨组织工程的概念、研究方法、研究现状及发展前景后,骨组织工程日益成为学者们研究的重点。目的:通过对1995年以来骨组织工程研究的进展的检索,探寻BMP-2和FGF-2在骨组织工程研究中的应用价值。方法:以"bone tissue engineering,BMP,FGF,cytokine"为检索词,应用计算机检索中国知网和pubmed数据库相关文章,排除重复性研究,保留36篇文章做进一步分析。结果与结论:骨组织工程的研究主要包括3个方面的内容:①种子细胞。②能引导组织再生的生物活性因子。③能够支持细胞黏附、增殖和分化以及释放生物活性因子的支架材料。细胞因子在骨组织工程中也拥有着不容忽视的重要地位,主要有有骨形态发生蛋白、骨转化生长因子、血管内皮生长因子、成纤维细胞生长因子,胰岛素样生长因子、血小板衍生生长因子等。其中骨形态发生蛋白2和成纤维细胞生长因子2在骨组织工程领域中应用最为广泛。

BACKGROUND：Bone tissue engineering becomes a research focus since its conception,method,condition and perspective was proposed systematically by Crane GM in 1995.OBJECTIVE：To seek the value of bone morphogenetic protein-2（BMP-2） and fibroblast growth factor-2（FGF-2） in bone tissue engineering research through retrieving the advanced of bone tissue engineering from 1995.METHODS：Articles published in CNKI and Pubmed databases were searched by computer with keyd words of ＂bone tissue engineering,BMP,FGF,and cytokine＂.According to inclusive and exclusive criteria,36 documents were remained for the further analysis.RESULTS AND CONCLUSION：Three main objects are applied to bone tissue engineering,including seed cell,cytokine and scaffold.Cytokine is very important in bone tissue engineering,which including bone morphogenetic protein,transforming growth factor,vascular endothelial growth factor,fibroblast growth factor,insulin-like growth factor and platelet-derived growth factor,et al.The bone morphogenetic protein-2 and fibroblast growth factor-2 are widely used in the bone tissue engineering.