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老年前列腺癌手术前后外周血调节性T细胞变化的临床意义 被引量：5

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摘要 目的探讨老年前列腺癌(PCa)患者手术前后外周血调节性T细胞(TrCs)比例的变化和临床意义。方法采用流式细胞技术检测14例老年PCa患者治疗前后和9例健康对照组外周血中T细胞亚群和CD4+CD25+TrCs的比例,观察其变化情况。结果老年PCa患者术前CD3、CD8较健康对照者降低,但差异无统计学意义(P>0.05);手术前后CD4均明显低于健康对照组,术前CD4+CD25+TrCs显著高于健康对照组和术后水平(P<0.05),术后水平与健康对照组无明显差异(P>0.05);老年PCa病理级别越高,外周血CD4+CD25+TrCs的比例越高,G3～4级者的外周血CD4+CD25+TrCs的比例显著高于中低级别PCa患者(P<0.05);术后CD4+CD25+TrCs降低,但差异无统计学意义(P>0.05)。结论老年PCa患者存在免疫功能失调和免疫抑制的情况;外周血CD4+CD25+TrCs比例的增加与PCa的病理分级有一定关系。
作者 李继清 冯国生 秦俭
机构地区 广西壮族自治区人民医院泌尿外科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2010年第7期904-905,共2页 Chinese Journal of Gerontology
关键词 PCa癌 CD4+CD25+调节性T细胞 流式细胞术
分类号 R737.25 [医药卫生—肿瘤]
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参考文献8

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二级参考文献8

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共引文献10

同被引文献61

引证文献5

二级引证文献6

中国老年学杂志
2010年 第7期

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