高压氧综合治疗蛛网膜下腔出血后迟发性脑血管痉挛的疗效观察

Therapeutic effect of hyperbaric oxygen theatment on delayed cerebrovasacular spasm after subarachnoid hemorhage

目的探讨高压氧对蛛网膜下腔出血后迟发性脑血管痉挛的疗效。方法回顾性分析2006年3月至2008年10月在我院治疗的42例动脉瘤蛛网膜下腔出血患者，高压氧组（21例）在常规治疗脑血管痉挛基础上辅以高压氧治疗，对照组（21例）采用常规方法治疗脑血管痉挛，对2组的临床疗效进行比较：结果高压氧组迟发性脑血管痉挛的发生率为14．3％，脑梗死发生率为4．8％；对照组迟发性脑血管痉挛的发生率为47．6％，脑梗死发生率为23．8％。高压氧组迟发性脑血管痉挛和脑梗死发生牢均较对照组低，2组比较差异有统计学意义（P〈0．05）。结论高压氧治疗对蛛网膜下腔出血迟发性脑血管痉挛有一定的效果。

Objective To evaluate the therapeutic efficacy of hyperbaric oxygen on delayed cerebrovasacular spasm （DCVS） after subaraehnoid hemorrhage. Methods Forty two patients with subaraehnoid hemorrhage were randomly divided into HBO treatment group （21 cases） and control group （21 cases）. The two groups were given the same treatment at first, and the HBO group was given HBO treatment additionally. Effect of therapy in the two groups were observed and compared. Results The incidence of DCVS was 14.3% in the HBO group and was 47.6% in the eontrol group. There was significant difference in the rate of DCVS between the 2 groups （P 〈 0.05）, the incidence of cerebral infarction was 4.8% in patients treated with HBO and was 23. 8% in the control group. There was significant difference in the rate of cerebral infarction between the 2 group （ P 〈 0.05 ）. Conclusions HBO might be a valuable agent for the treatment of DCVS after subarachnoid hemorrhage.