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北沙参中佛手柑内酯的分离鉴定及体外抗肿瘤活性的初步测定 被引量:31

Isolation and identification of bergapten in dry root of Glehnia littoralis and preliminary determination of its antitumor activity in vitro
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摘要 Using silica gel column chromatography and recrystallization,a light yellow needle crystal with a purity of 97.21% was obtained from ethyl acetate fraction of ethanol extract from dry root of Glehnia littoralis Fr.Schmidt ex Miq.,and was identified as bergapten by means of NMR.The experimental result of antitumor activity in vitro shows that 0.01-100.00 mg·L-1 bergapten have inhibitory effect to liver cancer cell line HEP-G2,in which inhibition of 100.00 mg·L-1 bergapten is the highest with an inhibitory rate of 95.0%.In concentrations of 0.01-100.00 mg·L-1,only 100.00 mg·L-1 bergapten has an inhibitory effect to stomach cancer cell line SGC-7901 with an inhibitory rate of 79.6%. Using silica gel column chromatography and recrystallization,a light yellow needle crystal with a purity of 97.21% was obtained from ethyl acetate fraction of ethanol extract from dry root of Glehnia littoralis Fr.Schmidt ex Miq.,and was identified as bergapten by means of NMR.The experimental result of antitumor activity in vitro shows that 0.01-100.00 mg·L^-1 bergapten have inhibitory effect to liver cancer cell line HEP-G2,in which inhibition of 100.00 mg·L^-1 bergapten is the highest with an inhibitory rate of 95.0%.In concentrations of 0.01-100.00 mg·L^-1,only 100.00 mg·L^-1 bergapten has an inhibitory effect to stomach cancer cell line SGC-7901 with an inhibitory rate of 79.6%.
机构地区 青岛农业大学
出处 《植物资源与环境学报》 CAS CSCD 2010年第1期95-96,共2页 Journal of Plant Resources and Environment
基金 山东省自然科学基金资助项目(Y2008D45)
关键词 北沙参 佛手柑内酯 分离鉴定 抗肿瘤活性 Glehnia littoralis Fr.Schmidt ex Miq. bergapten isolation and identification antitumor activity
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