青年女性脑外伤合并四肢长管状骨骨折患者血清雌二醇和泌乳素水平的观察

Estradiol and prolactin levels in young females with cerebral trauma combined with extremity long tubular bone fracture

目的 观察青年女性脑外伤合并四肢长管状骨骨折患者伤后不同时间段血清雌二醇（E2）及泌乳素（PRL）水平的变化.方法 2007年1月至2008年12月,对39例青年女性脑外伤合并四肢长管状骨骨折患者（观察组）和42例青年女性单纯四肢长管状骨骨折患者（对照组）均于伤后1～3 d、5～7 d、10～14 d、28～30 d和56～60 d时间段进行血清中E2和PRL浓度测定和比较. 结果 血清E2浓度比较中,观察组1～3 d、5～7d、10～14 d和28～30 d均明显高于对照组同期检测 结果 ,差异均有统计学意义（P〈0.05） 而56～60 d时间段两组差异无统计学意义（P〉0.05） 观察组其他时间段均明显低于1～3 d检测 结果 ,差异均有统计学意义（P〈0.05）,对照组各时间段间比较差异均无统计学意义（P〉0.05）.血清PRL浓度比较中,观察组全部时间段均明显高于对照组同期检测 结果 ,差异有统计学意义（P〈0.05） 观察组5～7 d、10～14 d和28～30 d时间段均明显高于1～3 d检测 结果 ,差异均有统计学意义（P〈0.05） 而56～60 d与1～3 d时间段比较差异无统计学意义（P〉0.05） 对照组各时间段间比较差异均无统计学意义（P〉0.05）.观察组的骨折愈合时间明显短于对照组,而前者住院总时间明显长于后者,差异均有统计学意义（P〈0.05）. 结论 青年女性脑外伤合并四肢长管状骨骨折的患者伤后早期E2和PRL水平明显升高.

Objective To investigate the estradiol （E2） prolactin （PRL） levels in young females with cerebral trauma combined with extremity long tubular bone fracture. Methods E2 and PRL were detected in 39 young females with cerebral trauma combined with extremity long tubular bone fracture （experimental group） and 42 young females with just extremity long tubular bone fracture （control group） at 1 to 3, 5 to 7, 10 to 14, 28 to 30, and 56 to 60 days after injury. Results E2 levels in the experimental group were significantly higher than in the control group at 1 to 3, 5 to 7, 10 to 14, and 28 to 30 days after injury （P 〈 0.05）, but there was no significant difference in the E2 level between the 2 groups at 56 to 60 days after injury （P 〉 0.05） . Compared with 1 to 3 days, the E2 level was significantly decreased in the experimental group at other time points （P 〈 0. 05）, while there was no significant difference in the E2 level in the control group among each time point （P 〉 0. 05）. PRL level in the experimental group was significantly higher than in the control group at all time points. In particular, the PRL level in the experimental group was significantly increased at 5 to 7, 10 to 14 and 28 to 30 days after injury, compared with that at 1 to 3 days after injury （P〈0.05）, but there was no significant difference in the PRL level between 56 to 60 days and 1 to 3 days （P 〉 0. 05）. Additionally, the PRL level did not change in the control group at all time points （P 〉 0.05）. Time of fracture healing in the experimental group was significantly shorter than in the control group, while the time of hospital stay in the experimental group was significantly longer than in the control group （P〈0.05）. Conclusion E2 and PRL levels increase remarkably in the young females with cerebral trauma combined with extremity long tubular bone fracture at an early onset stage.