多囊卵巢综合征患者代谢综合征的发生及临床特征的相关性

Clinical features of the metabolic syndrome in patients with polycystic ovary syndrome

目的:应用2004年中华医学会糖尿病学分会(Chinese Diabetes Society,CDS)代谢综合征的诊断标准探讨多囊性卵巢综合征(polycystic ovary syndrome,PCOS)患者中代谢综合征(metabolic syndrome,MS)的发生及临床特点。方法:对232例PCOS患者进行检测血脂、75 g葡萄糖耐量(oral glucose tolerance test,OGTT)及胰岛素释放实验;应用生化法检测血清中总胆固醇(total cholesterol,TC)、甘油三酯(triglycerides,TG)、低密度脂蛋白-胆固醇(low density lipoprotein cholesterol,LDL-C)及高密度脂蛋白-胆固醇(high density lipoprotein cholesterol,HDL-C)含量;应用酶氧化方法检测空腹及餐后1 h和2 h血糖含量;应用化学发光方法检测空腹及餐后1 h和2 h胰岛素含量。用SPSS 10.0软件对结果进行统计学分析。结果:PCOS患者中MS的发生率为31.9%(74/232)、高血糖发生率为30.6%(71/232)、高血压发生率为5.6%(13/232)、肥胖的发生率以及血脂代谢紊乱的发生率均为48.3%(112/232)。肥胖PCOS患者中MS的发生率及所有代谢异常参数的发生率均明显高于非肥胖者;具有MS的PCOS患者中所有代谢异常参数均高于不具有MS的患者。结论:本研究结果可能提示,根据CDS诊断标准,PCOS患者中MS的发生率低于欧美国家,与亚洲一些国家基本相似;随着年龄及体重指数(body mass index,BMI)的增加,MS的发生率明显增加。

Objective：To study characteristics of the metabolic syndrome（MS） in patients with polycystic ovary syndrome（PCOS） according to 2004 Diagnostic Criteria by the Chinese Diabetes Society（CDS）.Methods： A 75 g oral glucose tolerance test（OGTT） with plasma glucose and serum insulin（INS） levels was performed in 232 PCOS patients.Also,serum triglycerides（TG）,total cholesterol（TC）,high density lipoprotein（HDL） cholesterol and low density lipoprotein（LDL） cholesterol（HDL-C and LDL-C） were measured.Results： The rates of MS prevalence was 31.9%（74/232）in patients with PCOS.The rate of hyperglycaemia,high blood pressure,obesity and lipid metabolic disturbance were 30.6%（71/232）,5.6%（13/232）,48.3%（112/232）and 48.3%（112/232）,respectively.The rate of MS prevalence and all metabolic parameters were higher in obese than in non-obese patients with PCOS.Age,BMI and all metabolic parameters were higher in PCOS patients with MS than in those without MS.Conclusion： According to the CDS criteria,the rate of MS prevalence was lower than that of the West in our study,and similar to that of some Asian countries.MS prevalence increased with age and BMI in patients with PCOS.