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泛素连接酶APC/C和SCF复合物与肿瘤的关系 被引量：3

Relationship of ubiquitin-ligases APC/C and SCF complex to cancer
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摘要 Ubiquitin ligases are an important component in ubiquitination system,which can recognize substrate proteins specially to promote their degradation.Closely related to the generation and development of many tumors,ubiquitin ligases can regulate the growth,differentiation and apoptosis of cells by influencing protein stability,which makes them a potential new target for tumor molecular therapy.There are many kinds of ubiquitin ligases,mainly including APC/C and SCF complex.This article will introduce the structures and functions of these two kinds of ubiquitin ligases and their roles in the tumor generation and development. Ubiquitin ligases are an important component in ubiquitination system,which can recognize substrate proteins specially to promote their degradation.Closely related to the generation and development of many tumors,ubiquitin ligases can regulate the growth,differentiation and apoptosis of cells by influencing protein stability,which makes them a potential new target for tumor molecular therapy.There are many kinds of ubiquitin ligases,mainly including APC/C and SCF complex.This article will introduce the structures and functions of these two kinds of ubiquitin ligases and their roles in the tumor generation and development.
作者 李淑晶 毕海连 伍会健
机构地区 大连理工大学生命科学与技术学院
出处 《北京大学学报（医学版）》 CAS CSCD 北大核心 2010年第2期243-244,F0003,共3页 Journal of Peking University:Health Sciences
基金 国家自然科学基金(30670409 30771221) 国家高技术研究发展计划专项经费(863计划 2006AA02Z120)资助~~
关键词 泛素 泛素蛋白连接酶类 肿瘤 Ubiquitin Ubiquitin-protein ligases Neoplasms
分类号 Q78 [生物学—分子生物学]
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参考文献12

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二级参考文献32

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共引文献5

同被引文献16

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引证文献3

二级引证文献4

北京大学学报（医学版）
2010年 第2期

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