高血压脑损害患者血清Klotho蛋白水平测定及相关危险因素分析

Serum Klotho protein in hypertensive patient with brain harm and analysis of associated risk factors

目的检测高血压脑损害患者血浆Klotho蛋白水平的变化,探讨高血压脑损害的发病机制及相关的危险因素。方法选取本科2007年9月至2008年3月留院观察的高血压、高血压合并脑损害患者及体检中心健康群共190例,分为高血压无脑损害组、高血压脑损害组与正常对照组。检测3组血清Klotho蛋白浓度与血清胆固醇、肌酐、血糖、血压水平,并针对以上因素及年龄和高血压病史等危险因素进行相关性分析。结果正常对照组血清Klotho蛋白浓度[(13.29±4.66)pg/ml]明显高于高血压无脑损害组[(8.66±3.08)pg/ml]与高血压脑损害组[(4.68±2.21)pg/ml](P<0.05),同时高血压无脑损害组明显高于高血压脑损害组(P<0.05)。血清Klotho蛋白浓度与高血压及高血压脑损害患者的胆固醇、肌酐、血糖、血压、年龄、性别以及高血压病史等均存在负相关(r值分别为-0.111、-0.225、-0.289、收缩压-0.428、舒张压-0.211、-0.404、-0.206、-0.516),胆固醇、肌酐、血糖、血压等越高、年龄越大以及高血压病史等越长,血清Klotho蛋白浓度越低。结论血清Klotho蛋白浓度增加可能是高血压及高血压脑损害的保护性因素;高血压患者定期检测血清Klotho蛋白浓度可能有助于早期监测高血压脑损害。

Objective To explore the changes of the Klotho protein expression in blood serum of hypertensive patients with brain harm,so as to investigate the incidence mechanism of brain harm caused by hypertension and the associated risk factors.Methods The research objects were recruited from the hypertensive in-patients and healthy individuals from health examination during September 2007 to March 2008 in our hospital.There were 56 hypertensive patients without syndrome,104 hypertensive patients with brain harm,and 30 normal control individuals,They all were marched in sex and age.Klotho protein concentration of blood serum,cholesterin,creatinine,blood glucose and blood pressure of these 3 groups were tested.And correlation analysis of the above factors and the patients＇ ages and hypertension medical records was performed.Results The Klotho protein concentration of blood serum in the normal control group was obviously higher than that of the hypertensive patients without syndrome and those with brain harm（P〈0.05）;The Klotho protein concentration of blood serum of the hypertensive patients without syndrome was obviously higher than that of the hypertensive patients with brain harm（P〈0.05）.The Klotho protein concentration of blood serum was negatively pertinent with hypertension and the cholesterol,creatinine,blood glucose,blood pressure,age,sex and hypertension medical record of the hypertensive patient with brain harm.The higher the cholesterol,creatinine,blood glucose and blood pressure was,the older the age was,and the longer hypertension medical record was,the lower the Klotho protein concentration of blood serum was.Conclusion The increase of the Klotho protein concentration might be a protective factor of hypertension and brain harm caused by hypertension.In order to monitor and prevent brain harm caused by hypertension at the early stage,it is beneficial for the hypertensive patient to have a test of the Klotho protein concentration of blood serum regularly.